Enhancement of experimental ulcers by angiotensin-converting enzyme inhibitor and angiotensin II receptor antagonist

Angiotensin Converting Enzyme in Sarcoidosis

Effect of Angiotensin II Type I Receptor Antagonist and Angiotensin-Converting Enzyme Inhibitor on Vitamin D Receptor Null Mice

Running title: Effect of ACE and AT 1 blockers on VDR null mice Abstract We have recently shown that vitamin D receptor (VDR) inactivation results in deregulated stimulation of the renin-angiotensin system (RAS). To address further the relationship between RAS activation and the abnormalities in electrolyte and volume homeostasis, we studied the effect of AT 1 receptor antagonist losartan and a...

Angiotensin-converting Enzyme Inhibitor

The hemodynamic effects of an oral angiotensin-converting enzyme inhibitor, captopril, were evaluated in 10 symptomatic patients with chronic congestive heart failure. In all patients there was a significant increase in cardiac output (average 28%), stroke volume (49%), and stroke work index (26%), along with a decrease in pulmonary capillary wedge pressure (48%), indicating improved left ventr...

Angiotensin-converting Enzyme Inhibitor

The effects of angiotensin-converting enzyme inhibitor (CEI) SQ14225 on infarct size and regional myocardial blood flow were studied in 21 anesthetized dogs subjected to 6 hours of coronary occlusion. An area of myocardium at risk of necrosis was determined in vivo after 15 minutes of coronary occlusion but before CEI treatment (AR1) using an autoradiographic technique and after treatment after...

Effects of Angiotensin Converting Enzyme Inhibitor Versus Angiotensin II Receptor Blocker

Background. The degree of cardiac hypertrophy is not only load dependent: Among other factors, the renin-angiotensin system may play a role in the regulation of cardiac myocyte growth. Methods and Results. To evaluate the role of the renin-angiotensin system in volume overload-induced cardiac hypertrophy, we assessed 1) the time course of changes in cardiac hemodynamics, cardiac anatomy, and pl...